Steve Rosenfeld, chair of the PSON Brain Tumor Working Group, and Jann Sakaria, an investigator in the MIT/Mayo PSOC and the Mayo Brain Tumor SPORE, organized a meeting in Amelia Island Florida to explore opportunities to connect the PSON and SPORE brain tumor research communities. The group identified key questions and knowledge gaps in the field that are impeding progress in the development of effective brain tumor therapies.