Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices (2017)

[3] Ray A, Slama ZM, Morford RK, Madden SA, Provenzano PP Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices, Biophysical Journal, 112(5):1023-1036, 2017

This work demonstrates the unique dynamics of cancer stem cells during directed cell migration by contact guidance in aligned collagenous extracellular matrix.  Further, we show that a high degree of phenotypic plasticity and increased protrusive activity emerge as vital facilitators of rapid contact guided migration of CSCs.

nadka010